Introduction to our study and collaboration:
In the period from 1993 to 1996, through a collaboration between the Cancer Research Center of Hawaii/ University of Hawaii (CRCH/UH) and the University of Southern California (USC), we established a prospective multiethnic cohort study (MEC) of some 215,000 men and women in Hawaii and California (largely Los Angeles County). The participants were primarily native Hawaiians, Japanese, and Whites in Hawaii and African-Americans and Latinos in Los Angeles. The main aim of this study is the evaluation of dietary and other environmental contributions to the racial-ethnic variability in cancer risk [Kolonel et al., 2000]. In 1999, we established a collaboration with the Whtehead Center for Genome Research (now the Broad Institute) at MIT, to merge genomic resources with the MEC in an attempt to comprehensively evaluate genetic susceptibility to breast, prostate, colorectal, and other cancers. The combination our large population-based cohort and innovative genomic resources at the Broad Institute allows us to develop new methodology and further our investigation of cancer susceptibility genes in largely unstudied populations with highly variable risk of disease.
How-to Tools
NCI Cohort Consortium - The data presented here is the most current available (4 January 2005). Taqman Genotyping Call Key Broad/MEC Genes: Data, Haplotypes and Tagging SNPs Additional Genes at NCI Candidate Genes Studies Description of our approach Published Papers
Broad Institute at MIT
* Kolonel LN, Henderson BE, Hankin JH, Nomura AM, Wilkens LR, Pike MC, Stram DO, Monroe KR, Earle ME, Nagamine FS (2000) A multiethnic cohort in Hawaii and Los Angeles: baseline characteristics. Am J Epidemiol 151:346-357.
