Trial 2L-10-1

Collaborative Advanced Stage Tissue Lung Cancer (CASTLE) Network.

Type: Specimen Study
Phase: Not Applicable
Status: Open to Accrual
Treatments:
Randomized: No
Defintions of terms and FAQ about clinical trials.

Trial Leaders/Researchers: Barbara Gitlitz, M.D.
Other Trial Staff: Charlean Ketchens, R.N., Lagrimas Ilagan, D.M., Gina Tse, R.N., Eduardo Mejia, D.M.

Staff may log in to see study documents.

You may participate in this study if:

	Requirement
1	M1A or B NSCLC or any stage SCLC with any number of prior therapies
2	Planned systemic therapy
3	At least 18 years of age
4	Measurable or evaluable disease
5	ECOG performance status of 0-2
6	Expected survival at least 3 months
7	Tumor specimens: [a] First Priority: availability of a minimum of a 1 X 10 mm core fresh frozen tumor from clinically indicated interventional procedures, with no systemic anti-cancer therapy or radiation to the biopsy site between collection of the biopsy and entry into the study; OR [b] Second Priority: availability of paraffin-embedded tumor at least 5 X 5 mm cross-sectional tumor area, with no systemic anti-cancer therapy or radiation to the biopsy site between collection of the biopsy and entry into the study; the collection of the paraffin-embedded tissues may have taken place up to 12 months prior to enrollment in CASTLE.
8	Willingness to undergo all study collection procedures and sample analyses
9	Provision of written informed consent for biospecimen storage, broad genetic and proteomic analysis of tumor and normal tissues, without restrictions, AND correlation with outcome data.

You may not participate in this study if:

1	Other co-existing malignancies, except for basal cell carcinoma or cervical cancer in-situ
2	Compromise of patient diagnosis or staging if tissue is harvested for research

For further information on a study, please contact the Clinical Investigation Support Office at (323) 865-0451, or clinical.trials@med.usc.edu.

To schedule a consultation with the hospital, please call our New Patient Referrals Office at (323) 865-3111.